The other authors indicated no financial relationships. The New Yorker. All the above reported data thus point to a probable attribution of the trampled horizon to the late Early Triassic. Only one isolated track was visible on the underlying sandstone bed, also preserved as concave epirelief, possibly undertracks of the upper level. In addition, in I. lomasi pes digit group I–IV is detached from digit V. I. herculis (Egerton, 1839) (Fig. Übersetzung Italienisch-Deutsch für rivista im PONS Online-Wörterbuch nachschlagen! Use the link below to share a full-text version of this article with your friends and colleagues. (F) Time tree of all sequences containing the C2416T variant collected before September 30th 2020. Unfortunately, no bones of the fore- and hind-limbs are known from Arizonasaurus, as well as from Ctenosauriscus koeneni (Von Huene, 1902) (Germany, latest Olenekian), a Lower Triassic poposauroid archosaur, and additionally findings are needed to test Diedrich’s hypothesis. The hind-limb bones are known in Lotosaurus adentus (Zhang, 1975) (China, Ladinian; Fig. STEAM (NCT01765582) was a phase II, randomized trial that enrolled 280 patients and showed that first‐line concurrent FOLFOXIRI‐bevacizumab and sequential FOLFOXIRI‐bevacizumab were well tolerated regimens with numerically improved objective response rate, PFS, and liver resection rates compared with FOLFOX‐bevacizumab [10]. It is slightly longer than II, whereas digit IV imprint is shorter than II. PNQ: “Ponte di Nava Quartzites”, CVP: Case Val Marenca Pelites. Based on a phylogenetic dataset made by 108 middle Permian–early Late Triassic species, Ezcurra & Butler (2015) investigate principal patterns of early archosauromorph biodiversity change across the Permo-Triassic mass extinction. Drawing from these considerations, we performed a propensity score‐based analysis including data from five RCTs with the aim of comparing the efficacy and safety of FOLFOXIRI‐bevacizumab versus FOLFOX‐panitumumab in the subgroup of patients with left‐sided RAS and BRAF wild‐type mCRC. F ST distributions statistically lower than the Italian one are in colors other than green. The sedimentary rock belonging to the quartz-rich clastic succession does not allow precise dating because of the lack of biostratigraphic markers as commonly happen for these kind of deposits. Tipografia del libro, Guide geologiche regionali, 11 itinerari, Alpi Liguri (a cura della SGI), Vertebrates from the upper Moenkopi formation of Northern Arizona, Ammonoid diversity and disparity track episodes of chaotic carbon cycling during the early Mesozoic, Large igneous provinces and mass extinctions, Integrating ichnofossil and body fossil records to estimate locomotor posture and spatiotemporal distribution of early sauropod dinosaurs: a stratocladistic approach, Chirotherium trackways from the Middle Triassic of Guizhou, China, Late Palaeozoic–Early Mesozoic plate boundary reorganization: collapse of the Variscan orogen and opening of Neotethys, Permian continental deposits of europe and other areas. The described material is represented by a footprint still in situ. III. Chemotherapy‐related adverse events were more frequent in the FOLFOXIRI‐bevacizumab group, with specific regard to grade 3 and 4 neutropenia (48% vs. 26%, adjusted p = .001). Manus consistently smaller than the pes and placed medially in front of the pes; manus digit III impression parallel to digit III trace of the pes. Chemotherapy‐related adverse events were more frequent in the FOLFOXIRI‐bevacizumab group. The Kaplan‐Meier method and Cox proportional hazards regression model were used for survival analysis. Conclusions gènèrales à ètude du gisement, Nouvelles observations sur la zone briançonnaise au delà de la frontiére franco-italienne (Bassin de la Haute Maira, Province de Cuneo), Les chainons briançonnais et subbriançonnais de la rive gauche de la Stura entre la Val de l’Arma (province de Cuneo-Italie), Carte géologique détaillée de la France à l’échelle 1/50.000, feuille Larche, 1° édition. Although randomized comparison is lacking, both FOLFOXIRI‐bevacizumab and FOLFOX‐panitumumab are valuable treatment options in left‐sided RAS/BRAF wild‐type mCRC. Two possible trackways with lengths of 4–5 m were identified on a track surface. The authors declare there are no competing interests. Rubén López-Bueno, Guillermo F. López-Sánchez, José A. Casajús, Joaquín Calatayud, Alejandro Gil-Salmerón, Igor Grabovac, Mark A. Tully, Lee Smith, Health-Related Behaviors Among School-Aged Children and Adolescents During the Spanish Covid-19 Confinement, Frontiers in Pediatrics, 10.3389/fped.2020.00573, 8, (2020). We selected patients with left‐sided RAS and BRAF wild‐type mCRC treated with first‐line FOLFOX‐panitumumab or FOLFOXIRI‐bevacizumab in five randomized trials: Valentino, TRIBE, TRIBE2, STEAM, and CHARTA. Isochirotherium coltoni (Peabody, 1948) (Fig. Govoni et al. Disclosures of potential conflicts of interest may be found at the end of this article. (Fig. TRIBE (NCT00719797) was a multicenter, randomized, open‐label phase III trial that enrolled 508 patients and showed that first‐line FOLFOXIRI‐bevacizumab achieved superior PFS and overall survival (OS) compared with FOLFIRI‐bevacizumab in patients with molecularly unselected mCRC [7]. The results of the propensity score‐matched sensitivity analysis were consistent with the propensity score‐adjusted analysis (supplemental online Table 1). Digit III impression is the longest. The main diagnostic features of this ichnogenus, recognized in our specimens are: (i) the relative digit length, with digit II longer than IV and shorter than III; (ii) a marked heteropody; (iii) the pes pace angulation around 165°; (iv) the weakly impressed distal portion of digit V and (v) pes-manus couples outward rotation of about 15°. The Gardetta ichnosite is characterized by archosaur-grade footprints assigned to Chirotherium isp. The here described material, even if not perfectly preserved, retains some diagnostic features of the ichnogenus Chirotherium, such as the oval morphology and the position of digit V imprint (slightly behind digit group II–IV), and the relative digit length of group II–IV, with digit IV longer or sub-equal to digit II impression. The nonmarine Permian, Greenhouse crises of the past 300 million years, Methane release from igneous intrusion of coal during Late Permian extinction events, Multiple Early Triassic greenhouse crises impeded recovery from Late Permian mass extinction, Early Triassic terrestrial tetrapod fauna: a review, Corroborating trackmaker identification through footprint functional analysis: the case study of, The Chanares (Argentina) Triassic reptile fauna XI. Abbreviations: B, bevacizumab; P, panitumumab; PS, propensity score. Why was there a delayed radiation after the end-Palaeozoic extinctions? The trackway, made by three consecutive manus-pes sets, shows a clear narrow gait (pace angulation 164°). The distribution of propensity scores after matching is shown in supplemental online Figure 2. This is leading to significant volumes of shells, rich in biorenewable calcium carbonate, being discarded. Discussion . The 3D model of the holotype is digitally stored in MorphoSource:, DOI: 10.17602/M2/M166068. The gas can emit at radio wavelengths if it contains electrons at relativistic speeds, which can be injected by active galaxies or accelerated during a merger between two clusters. During locomotion the former was held off the ground whereas the latter was likely being retracted due to the presence of a thick fleshy pad beneath calcaneum and astragalus. The reverse Kaplan‐Meier method was used for follow‐up time assessment. For the present analysis, we selected patients with RAS and BRAF wild‐type tumors originating from the splenic flexure, descending colon, sigma, and rectum, treated with first‐line FOLFOXIRI‐bevacizumab or FOLFOX‐panitumumab in 5 RCTs: Valentino, TRIBE, TRIBE2, CHARTA, STEAM. No significant differences in overall response rate and disease control rate were observed. Close-range photogrammetry was used to document tracks and obtain three-dimensional model of the best-preserved ones (Petti et al., 2008; Remondino et al., 2010; Mallison & Wings, 2014). Advance Magazine Publishers Inc is responsible for this Page. Solar-driven reforming of plastics offers a simple and low-energy means to turn waste into H2. Digit impressions are short and pointed. Progress towards green and autonomous energy sources includes harnessing living systems and biological tissue. This discovery provides reliable evidence of the presence of archosauriforms in the Briançonnais domain during the Early Triassic, adding further support to the occurrence of terrestrial tetrapods at low latitudes soon after the PTME (Bernardi et al., 2015; Bernardi, Petti & Benton, 2018; Romano et al., 2020) and well-before a full land ecosystem recovery. testifies to the evolution of a continental margin affected by extensional tectonics. Question Is third-line cetuximab plus irinotecan an active option for patients with RAS and BRAF wild-type metastatic colorectal cancer who have acquired resistance to first-line irinotecan- and cetuximab-based therapy?. In all the three representatives Proterosuchus fergusi (Broom, 1903) (South Africa, Induan–?early Olenekian; Fig. The outcropping lithostratigraphic units, even if they can be correlated across the distinct domains, display different thickness, vertical/lateral relationships and hiatuses. Similar results were observed in the propensity score‐matched sensitivity analysis (supplemental online Table 3). trackmaker. Being metatarsal length directly proportionate to digit length, this assumes that metatarsal IV is shorter than or as long as metatarsal III, a synapomorphy of the archosauriforms (Nesbitt, 2011). The upper dolomitic complex (Fig. Isochirotherium trackways, their possible trackmakers (? Research indicates that core dimensions of psychological well-being can be cultivated through intentional mental training. 9E), Chanaresuchus bonapartei (Romer, 1971) (Argentina, Ladinian; Fig. A total of 317 patients with left‐sided RAS and BRAF wild‐type mCRC were included in the propensity score‐adjusted analysis: 185 treated with FOLFOX‐panitumumab and 132 with FOLFOXIRI‐bevacizumab. The process of patients’ selection is illustrated in supplemental online Figure 1. Valentino (NCT02476045) was a multicenter, randomized, open‐label phase II trial that enrolled 229 patients and showed that, in patients with RAS wild‐type mCRC, FOLFOX‐4 plus panitumumab followed by maintenance with single‐agent panitumumab (arm B) achieved inferior progression‐free survival (PFS) compared with the same induction regimen followed by panitumumab plus 5‐fluorouracil/leucovorin (arm A) [15]. In properly selected patients, both FOLFOXIRI‐bevacizumab and FOLFOX/FOLFIRI plus anti‐EGFRs are highly active upfront regimens able to significantly increase patients’ survival thanks to a deep impact on the initial and subsequent disease course, including the conversion to secondary resection of metastases and maximal shrinkage of initial tumor burden. According to models of Solar System formation, Earth, as an inner Solar System planet, should have little to no water. These tectonic units pertain to the Briançonnais Domain (Gidon, 1958a; Gidon, 1958b; Gidon, 1972; Schmid et al., 2004; Schmid et al., 2017) and in particular to the External Briançonnais Domain which is characterized by very low grade to anchizone metamorphism (D’Atri et al., 2016). Adopting the paleolatitude calculator developed by Van Hinsbergen et al. Common use cases PeerJ promises to address all issues as quickly and professionally as possible. 10). Inchiostro, la più longeva rivista italiana di narrativa, è il punto di riferimento per gli scrittori esordienti. They represent the first record of terrestrial tetrapods in the Briançonnais domain of the Western Alps and expand the record of archosaur-grade footprints in the Lower Triassic of Central Europe. This is consistent with the under‐representation of patients with left‐sided RAS and BRAF wild‐type tumors in clinical trials investigating the efficacy of the intensification of the upfront chemotherapy backbone in combination with bevacizumab. We acknowledge that the two limitations of our analysis are the retrospective nature without a formal a priori hypothesis and the lack of randomization. as possible trackmaker candidate (even though the presence of crown-archosaurs cannot be excluded), thus providing crucial information about continental tetrapod occurrence in Europe in the Early Triassic. Recent work claimed to have reached this point, but subsequent work managed to speed up the classical simulation and pointed toward a sample size–dependent loophole. Abstract Background RET fusions are oncogenic drivers in 1 to 2% of non–small-cell lung cancers (NSCLCs). Referred specimens: two trackways preserved as concave epirelief (GT-1 and GT-2). The total divarication I–IV is 22°; the angle between digit I and II is 8° and is equal to that between the impressions of II and III but larger than II–IV (6°). The tracks referred to Isochirotherium delicatum (Courel & Demathieu, 1976) and found in the Anisian-Ladinian deposits of Argentière (Ardèche, France; Courel & Demathieu, 1976; Courel, Demathieu & Gall, 1979; Demathieu, 1984; Gand, 1978) and Gampempass (Southern Alps, Italy; Avanzini & Lockley, 2002) show less-thick digit impressions and a markedly reduced digits IV and V; the latter is also much more backward positioned if compared with the studied specimens. In particular, the early diversification of main taxa, which include erythrosuchids, rhynchosaurs and tanystropheids, resulted in significantly high evolutionary rates, with a diversification interpreted by the authors as a radiative response to vacant ecological space, made available by the EPME (Ezcurra & Butler, 2015). Derivatio nominis: from the Gardetta plateau, type locality of the ichnospecies. Only patients with measurable disease at the time of randomization and at least one instrumental evaluation of tumor response were included in activity analyses. In the best-preserved track (GT1-3; Figs. ist das Online-Magazin für Fotoschaffende in der Schweiz. In the Alps, chirotherian footprints were described from the upper Permian, Lower to Middle Triassic of the Dolomites, Piedmont and Ligurian Alps in Italy (Avanzini & Mietto, 2008; Petti et al., 2013; Bernardi et al., 2015; Santi et al., 2015), Aar Massif in eastern Switzerland (Feldmann, Furrer & Glarus, 2009; Klein et al., 2016) and the Aiguilles Rouges Massif (Western Alps), on the border between Switzerland and France (Demathieu & Weidmann, 1982; Avanzini & Cavin, 2009; Cavin et al., 2012; Klein et al., 2016). The First Fashion Forward Magazine in Cambodia. There is increased production of shellfish worldwide to meet global needs for protein. Rivista on line di cultura filatelica e storico postale Iscrizione Tribunale di Arezzo n. 1326/04 del 28 settembre 2004 Direttore responsabile: Roberto MONTICINI The Briançonnais domain was positioned north of the westernmost sector of the Palaeotethys, in the western continental termination of the Meliata oceanic back-arc basin (Ziegler & Stampfli, 2001; Decarlis et al., 2013). Propensity score (i.e., the probability of receiving FOLFOXIRI‐bevacizumab conditional on examined baseline characteristics) was calculated by means of a multivariable logistic regression model. 8H) and I. lomasi (Baird, 1954) (Fig. A propensity score‐adjusted analysis was used to estimate the effect of the treatment groups on clinical outcomes. Please check your email for instructions on resetting your password. Fabio Massimo Petti conceived and designed the experiments, performed the experiments, analyzed the data, prepared figures and/or tables, authored or reviewed drafts of the paper, and approved the final draft. The median follow‐up time was 36.5 months (IQR, 31.6–44.4) for patients treated with FOLFOX‐panitumumab and 44.3 months (IQR, 33.3–51.4) for patients treated with FOLFOXIRI‐bevacizumab. The search for a putative trackmaker was carried out employing three different and integrated methodological approaches: (i) Synapomorphy-based correlation (Olsen, 1995; Carrano & Wilson, 2001); (ii) Phenetic correlation (Carrano & Wilson, 2001) and (iii) Coincidence correlation (Carrano & Wilson, 2001). Subgroup analyses were performed only using the propensity score‐adjusted method because of the loss of precision due to extremely small sample sizes. However, the studied trackway shows clear difference to most of the ichnospecies known to date. Quantum computational advantage, rather than being a one-shot experimental proof, will be the result of a long … (G) Brachyspira (red) penetrating into the crypt base. The outcrop is located along the SW flank of a narrow antiformal anticline belonging to the Sautron Tectonic Unit which overthrusts the Rouchouze Tectonic Unit. used a cohort of more than 30,000 infected individuals with mild to moderate COVID-19 symptoms to determine the robustness and longevity of the anti–SARS-CoV-2 antibody response. A graphical approach was used to assess the distribution of the propensity scores before and after matching. Postosuchus kirkpatricki (Chatterjee, 1985) (USA, Norian; Fig. In particular, by integrating both skeletal and ichnological material, recently Romano et al. Abbreviations: B, bevacizumab; CI, confidence interval; HR, hazard ratio; OS, overall survival; P, panitumumab; PFS, progression‐free survival. Regional reports and correlations, Loose slab currently stored at the Museo di Geologia e Paleontologia dell’Università di Torino. Conditional logistic regression was used in the propensity score matching analysis. However, digit V impression in I. gardettensis likely records only the distal metatarsal and phalangeal (ungual) portions. Description: pentadactyl and semi-digitigrade pes imprint. These carbonate deposits testify the sedimentation in a subsiding carbonate ramp. This biochron is characterized by the occurrence of Chirotherium and Isochirotherium, but also by two other ichnogenera not present at Gardetta: Rotodactylus, and Synaptychium. 11). The Gardetta outcrop enlarges also the knowledge on biogeography of archosauriforms in the Lower Triassic of Europe, so far based on archosaur ichnosites discovered in Italy (Val Marenca, Santi et al., 2015; Sardinia, Citton et al., 2020), Spain (Moncayo and Tagamanent, Díaz-Martínez & Pérez-García, 2012), Switzerland (Cascade d’Emaney and Vieux Emosson; Cavin et al., 2012), Austria (Drau Range; Krainer, Lucas & Ronchi, 2012), Germany (Bundsandstein; Klein & Haubold, 2007) and Poland (Wióry, Holy Cross Mountains, Klein & Niedźwiedzki, 2012). Fossil evidence from North-West England, Proterochampsia: an endemic archosauriform clade from South America, Anatomy, phylogeny and palaeobiology of early archosaurs and their kin, A paleolatitude calculator for paleoclimate studies, La serie brianzonese di Salto del Lupo (Liguria Occ. 2,974,007 likes. to Grange Isoardi (Pianezza area, 2,275 m a.s.l.) 8G) of the Adige Valley (Bolzano, NE Italy) closely resembles the Gardetta specimens for: (i) the arched metatarsal-phalangeal portion; (ii) the position of the base of pes digit V, placed along the axis of digit III; (iii) pes digit relative length; (iv) cross axis equal to 90° (v) pes angulation of about 160°; (vi) positive rotation of manus-pes couples respect to the midline (10° − 15°). nov. The baseline distribution of propensity scores is shown in supplemental online Figure 2. Working off-campus? Such physiological aspects and water conserving mechanisms, probably suggest that response of the archosauriforms to the extreme hot condition of the Early Triassic (Benton, 2018) have probably been much more efficient and flexible than previously thought, and did not necessarily imply massive dispersal towards higher latitudes as previously suggested (Sun et al., 2012). The ordered calcite array within waste mussel shells can be disrupted when treated with dilute acetic acid. (A) GT-1-3; (B) GT-2-3; (C) GT-2-8; (D) GT-2-6; (E), (F). Even if patients in the two treatment groups were enrolled in a relatively recent time frame, some unbalances in baseline prognostic features were due to differences in studies’ inclusion criteria in terms of age, ECOG PS, and prior adjuvant therapy. Furthermore, in I. marshalli the proximal pes sole-pad impression is more centrally located behind digit II and III whereas in I. gardettensis lies more externally behind digit group III–V. A proof-of-concept device for harvesting water at low relative humidity was reported; however, it used external cooling and was not desert-tested. 18 persone ne parlano. Abbreviations: B, bevacizumab; ECOG PS, Eastern Cooperative Oncology Group performance status; P, panitumumab. Different anatomical features described above indicate the erythrosuchids as the most probable trackmakers for the new described ichnospecies Isochirotherium gardettensis. When looking at specific adverse events, only neutropenia was significantly more frequent with the triplet plus bevacizumab. (2008). ): osservazioni sedimentologico-stratigrafiche, L’Unità di Ormea: una chiave per l’interpretazione del Brianzonese ligure. More recently, Bernardi et al. This recommendation is based on the results of the post hoc subgroup analyses of several randomized clinical trials (RCTs) showing a clear benefit from doublets plus anti‐EGFR when compared with doublets with or without bevacizumab in patients with RAS wild‐type tumors originating in the left side of the colon [2, 3]. The Permian-Triassic mass extinction (PTME) was the most severe biotic crisis of all times (Erwin, 1993), eliminating >90% of marine and terrestrial species (Erwin, 1993; Song et al., 2013; Song et al., 2015; Romano et al., 2020). Nonostante la pandemia globale da Covid-19, negli ultimi mesi del 2020 e nei primi giorni… In recent years the distribution of land tetrapods across the PTME was discussed in a number of studies which however suggested different scenarios. Therefore, although FOLFOXIRI‐bevacizumab is a valuable option for fit patients with more aggressive and treatment‐resistant cancers, it may achieve its maximal efficacy in the subgroup of patients with better prognosis and responsiveness to available agents, including chemotherapy and antiangiogenics. In our opinion, the sub-elliptical to pyriform impression behind group I-IV in Isochirotherium could be the result of the coalescence of the impression of the phalangeal-metatarsal portion of digit V and of a thick fleshy pad beneath the astragalus, the calcaneus and some of the tarsal bones. Pandora Rivista è uno spazio approfondimento, di carta e online, per capire il presente. The gait and fore- and hind limbs were reconstructed according to the pattern and morphologies of GT-7 trackway (artwork by Fabio Manucci). After the mass extinction, totally new clades emerged, which include decapods and marine reptiles in the oceans and new tetrapods on land (Chen & Benton, 2012). However, subgroup analyses of available RCTs suggest that patients with left‐sided RAS and BRAF wild‐type tumors may derive benefit from an intensified chemotherapy [8, 11, 12], and the inhibition of angiogenesis is demonstrated as an equally effective strategy in both right‐ and left‐sided tumors, independently of RAS and BRAF mutational status [13, 14]. We here describe and interpret a new Early Triassic (?Olenekian) archosauriform track assemblage from the Gardetta Plateau (Briançonnais, Western Alps, Italy) which, at the Permian-Triassic boundary, was placed at about 11° North. Learn about our remote access options, Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy, Oncology and Hemato‐oncology Department, University of Milan, Milan, Italy, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy, Unit of Medical Oncology 2, Azienda Ospedaliero‐Universitaria Pisana, Pisa, Italy, Klinik fur Innere Med IV, University Clinic Halle, Halle, Germany, GI Oncology, Sarah Cannon Research Institute, Nashville, Tennessee, USA, Unit of Medical Oncology 1, Department of Clinical and Experimental Oncology, Istituto Oncologico Veneto, IRCCS, Padua, Italy, Clinical Epidemiology Unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy, Correspondence: Chiara Cremolini, M.D., Ph.D., Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa and Unit of Medical Oncology 2, Azienda Ospedaliero‐Universitaria Pisana, Pisa, Via Roma 67, 56126, Pisa, Italy.